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<B>Leveraging Heterogeneity in Alzheimer's Disease to Assess Differences in
Longitudinal Progression </B>
   Lead Investigator:    Justin Miller
   Institution      :    Brigham Young University
   E-Mail           :    jmiller@byu.edu
   Proposal ID      :    1531
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   Proposal Description:
   <textarea name="description" rows="12" cols="85" wrap="virtual" readonly>Our overall objective is to evaluate etiological differences in Alzheimer's disease cases and identify subtypes of the disease that have different health trajectories. We will characterize etiologically distinct subtypes of Alzheimer's disease cases by evaluating health outcomes within and between subtypes. Our central hypothesis is that combinations of biomarkers and genetics significantly differ between individuals with Alzheimer's disease, allowing for subtype classification. The rationale underlying this proposal is that Alzheimer's disease is classified on a spectrum of neurodegeneration, and some individuals experience faster cognitive decline. To accomplish our overall objective, we will pursue the following specific aims:    Aim 1: Identify clusters of Alzheimer's disease patients based on combining biomarkers, cerebrospinal fluid markers, plasma, and neuroimaging.  Aim 2: Link genetic variants to phenotypic clusters.  Aim 3: Assess subtype-specific differences in disease progression. </textarea>